Barcelona's Victor Valdes is set to start as Spain's goalkeeper in their Confederations Cup clash against Uruguay at the Arena Pernambuco.
Captain Iker Casillas featured in friendly wins over Haiti and the Republic of Ireland last week, but is unlikely to get the nod on Sunday, as he has not played for his club side Real Madrid since January.
Coach Vicente del Bosque will have to choose between David Villa and Fernando Torres in attack, with Cesc Fabregas offering another alternative as a 'false nine' striker.
Uruguay forward Luis Suarez is available after missing Tuesday's World Cup qualifier win over Venezuela through suspension.
Boss Oscar Tabarez could name an attack-minded side with Suarez, Diego Forlan and Edinson Cavani all starting together.